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Jean-Marc VANACKER


Jean-Marc Vanacker
Born 1963, french
Professional address:
Team Physiopathology of Orphan Nuclear Receptors
Institut de Génomique Fonctionnelle de Lyon
UMR 5242 CNRS/INRA/Université Claude Bernard LyonI
Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07
E-mail : jean-marc.vanacker@ens-lyon.fr

Research activities:
1993: PhD, Pasteur Institute, Lille.
1993-1996: Post-doc fellow, DKFZ, Heidelberg, Germany.
1996-1999: Post-doc fellow, Biology Institute, Lille, and Ecole Normale Supérieure, Lyon France.
1999 : Junior researcher, CR CNRS.
2004-07: PI of an independent research team, Cancer Center, Montpellier
2007-: PI of team "Physiology of Orphan Nuclear Receptors", Institut de Génomique Fonctionnelle de Lyon, CNRS UMR 5242. 7 members. See http://igfl.ens-lyon.fr/teams/team8 for details
2007: Senior researcher (Directeur de Recherche) CNRS
2009-2010 : Director animal facility (ENS Lyon, 20,000 mice ; 13 personals)
2010-: Academic Editor in PLoS-ONE
Reviewer for various publications and grant applications (Inserm, France ; RGC HongKong ; French Association for Cancer Research…)
Member of various selection committes (Associate Pr and Pr recruitment in Clermont-Fd ; Interface INSERM etc)

Present team structure
2 additional senior researchers, 1 PhD, students, 2 technician,

Areas of interest (keywords)
Nuclear receptors; breast cancer ; bone homeostasis ; cell migration ; regulation of transcription

Last publications (among 58 peer-reviewed altogether):
- Bianco S, Lanvin O, Tribollet V, Macari C, North S, Vanacker JM 2009 Modulating ERRa activity inhibits cell proliferation. J. Biol Chem 284: 23286-23292.
- Teyssier C, Gallet M, Rabier B, Monfoulet L, Dine J, Macari C, Espallergues J, Horard B, Giguère V, Cohen-Solal M, Chassande O, Vanacker JM 2009 Absence of ERRa in female mice confers resistance to bone loss induced by age or estrogen-deficiency. PLoS-ONE. 4: e7942
- Vico L, Vanacker JM 2010 Sex hormones and their receptors in bone homeostasis: insights from genetically modified mouse models. Osteoporos Int 21: 365-373
- Gauthier K, Billon C, Bissler M, Beylot M, Lobaccaro JM, Vanacker JM, Samarut J. 2010 Thyroid hormone receptor  (TR) and liver X receptor (LXR) regulate carbohydrate response element binding protein (ChREBP) expression in a tissue selective manner. J Biol Chem 285:28156-28163
- Gallet M, Vanacker JM 2010 ERR receptors as potential targets in osteoporosis. Trends Endocrinol. Metab 21: 637-641
- Macari C, Teyssier C, Tribollet V, Mouzat K, Forcet C, Horard B, Lobaccaro JM, Vanacker JM 2010 Estrogens repress PGC-1 in the uterus. Mol Cell Endocrinol 330: 33-40
- Bianco S, Sailland J, Vanacker JM 2012 ERRs and cancer: effects on metabolism and on proliferation and migration capacities J Steroid Biochem Mol Biol 130: 180-185.
- Gaude H, Aznar N, Delay A, Bres A, Buchet-Poyau K, Caillat C, Vigouroux A, Rogon C, Woods A, Vanacker JM, Höhfeld J, Perret C, Meyer P, Billaud M, Forcet C. 2012 Molecular chaperone complexes with antagonizing activites regulate stability and activity of the tumor suppressor LKB1. Oncogene 31: 1582-1591.
- Gallet M, Saïdi S, Haÿ E, Photsavang J, Marty C, Sailland J, Carnesecchi J, Tribollet V, Bruno Barenton, Christelle Forcet, Birling MC, Sorg T, Chassande O, Cohen-Solal M, Vanacker JM 2013 Repression of osteoblast maturation by ERR accounts for bone loss induced by estrogen deficiency. PLoS-ONE 8: e54837.
- Carnesecchi J, Vanacker JM 2013 The Estrogen-Related Receptors and the adipocyte. Horm Mol Biol Clin Invest 14 : 107-112.
- Zou C, Yu S, Ng CF, Yao X, Vanacker JM, Chan FL 2014 Estrogen-related receptor alpha promotes hypoxic growth of prostate cancer cells by enhancing HIF-1a protein expression via direct interaction. J Pathol. 233:61-73.
- van der Laan S, Golfetto E, Vanacker JM, Maiorano D. 2014 Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse ESCs. PLoS One. 9:e93663
- Sailland J, Tribollet V, Billon C, Barenton B, Carnesecchi J, Forcet C, Gauthier K, Yu S, Giguère V, Chan FL, Vanacker JM. 2014 ERRa promotes cell migration through regulation of RHOA protein stability. Proc Natl Acad Sci USA. 111 : 15108-15113
- Carnesecchi J, Malbouyres M, de Mets R, Balland M, Beauchef G, Vié K, Chamot C, Lionnet C, Ruggiero F, Vanacker JM. 2015 Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. PLoS-ONE 10 :e0120672

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Last update April 23, 2015
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