Accès direct au contenu

 

logo du site ENS

Retour à l'accueil du site

Search

Accueil  >  Projects

Print

Physics (QuDip)

QuDip: Quantum Correlations in Ultra-Cold Dipolar Molecules

The research project is under the co-supervision of

Yong XIA                                          
(State Key Laboratory of Precision Spectroscopy, ECNU)                                              
and
Tommaso ROSCILDE
(Laboratoire de Physique, ENSL)



SUMMERY


Lipid droplets (LDs) are dynamic organelles composed of neutral lipids and surrounded by a single phospholipid monolayer. There is growing evidence that dysregulation of lipids is associated with neurodegeneration in pathologies such as Alzheimer's and Parkinson's diseases. However, a protective or deleterious role of LDs is still debated. Recently, it was shown that lipid droplets accumulate in cells in response to endoplasmic reticulum stress (ER) which is induced by impaired folding capacity of proteins. To restore ER homeostasis, Unfolded Protein Response (UPR) pathways (IRE1, ATF6 and PERK) are activated upon accumulation of misfolded proteins. The regulated IRE1-dependent decay (RIDD) is an important pathway required for the mRNA decay of mRNA encoding FATP (Fatty acid transport protein), a central protein in lipid homeostasis that is required for LD formation and photoreceptor survival.

In this proposal, we will evaluate the importance of the RIDD pathway on LD formation and neuron survival in physiological in both Drosophila retina and human neuroblastoma cells lines. Specifically, it will be tested the link between the IRE1/RIDD and lipid metabolism and its impact on neuronal function and survival in these models. The long-term objective of this project is to open therapeutic perspectives in neurodegenerative diseases.

 

Top of the page

 
 
Last update October 11, 2018
Ens de Lyon
15 parvis René Descartes - BP 7000 69342 Lyon Cedex 07 - FRANCE
Tél. : Site René Descartes (siège) : +33 (0) 4 37 37 60 00 / Site Jacques Monod : +33 (0) 4 72 72 80 00