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Vincent Laudet

Vincent Laudet, PhD & Professor of Biology
Ecole Normale Supérieure de Lyon
Institut de Génomique Fonctionelle de Lyon (CNRS UMR 5242)
Leader of the research team working on evolution of nuclear hormone receptors.
After studying molecular biology in Montpellier and Strasbourg, he started research working on the v-erbA oncogene in Dominique Stéhelin's laboratory at the Pasteur Institute of Lille. V-erbA turns out to be a viral counterpart of the thyroid hormone receptor  gene and this was the start of his interest in nuclear hormone receptors. Having a constant interest in molecular evolution and natural history he started an evolutionary analysis of the nuclear hormone receptors.
Vincent Laudet obtained his PhD degree in 1992 and established as a group leader in 1994. He moved in 1997 to the Ecole Normale Supérieure de Lyon.

His laboratory has developed expertise in the analysis of the phylogeny and evolution of the nuclear receptor superfamily. It is known for having produced the first classification of this superfamily and having derived from this an official nomenclature that is used worldwide.
His research group has also a general expertise on nuclear receptors mainly devoted to orphan receptors (Rev-erb, ERR) but also on liganded ones (TR, RAR, RXR). The present domains of research of his laboratory include analysis of the origin of nuclear receptors signalling systems such as thyroid hormones, estrogens or retinoic acid. Using amphioxus as a model system his team scrutinized the origins of the thyroid hormones and their role in post-embryonic development. More recently he has developed zebrafish embryos to detect in vivo endocrine disrupters acting by modulating the transcriptional activity of NRs.
Vincent Laudet's laboratory has contributed to more than 150 scientific papers and 30 reviews including two books on molecular endocrinology, molecular evolution, genomics and developmental biology.

Selected publications

Scientific papers
164. Samarut E, Amal I, Markov GV, Stote R, Dejaegere A, Laudet V, Rochette-Egly C. Evolution of nuclear retinoic acid receptor alpha (RAR{alpha}) phosphorylation sites. Serine gain provides fine-tuned regulation. Mol Biol Evol. 2011 Feb 5.
162.  Gibert Y, Sassi-Messai S, Fini JB, Bernard L, Zalko D, Cravedi JP, Balaguer P, Andersson-Lendahl M, Demeneix B, Laudet V. Bisphenol A induces otolith malformations during vertebrate embryogenesis. BMC Dev Biol. 2011 Jan 26;11:4.
154. Gibert Y, Bernard L, Debiais-Thibaud M, Bourrat F, Joly JS, Pottin K, Meyer A, Retaux S, Stock DW, Jackman WR, Seritrakul P, Begemann G, Laudet V. Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signaling.  FASEB J  2010, Sept 24(9):3298-3309.
146. Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V: Independent elaboration of steroid hormone signaling pathways in metazoans. Proc Natl Acad Sci U S A 2009, 106:11913-11918.
132. Paris M, Pettersson K, Schubert M, Bertrand S, Pongratz I, Escriva H, Laudet V: An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution. BMC Evol Biol 2008, 8:219.
126. Paris M, Escriva H, Schubert M, Brunet F, Brtko J, Ciesielski F, Roecklin D, Vivat-Hannah V, Jamin EL, Cravedi JP, et al: Amphioxus postembryonic development reveals the homology of chordate metamorphosis. Curr Biol 2008, 18:825-830.
124. Nishio S, Kakizawa T, Chatelain G, Triqueneaux G, Brunet F, Rambaud J, Lamonerie T, Laudet V: OTX5 regulates pineal expression of the zebrafish REV-ERB alpha through a new DNA binding site. Mol Endocrinol 2008, 22:23-32.
123. Bertrand S, Thisse B, Tavares R, Sachs L, Chaumot A, Bardet PL, Escriva H, Duffraisse M, Marchand O, Safi R, et al: Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. PLoS Genet 2007, 3:e188.
114. Escriva H, Bertrand S, Germain P, Robinson-Rechavi M, Umbhauer M, Cartry J, Duffraisse M, Holland L, Gronemeyer H, Laudet V: Neofunctionalization in vertebrates: the example of retinoic acid receptors. PLoS Genet 2006, 2:e102.
92. Schubert M, Holland ND, Escriva H, Holland LZ, Laudet V: Retinoic acid influences anteroposterior positioning of epidermal sensory neurons and their gene expression in a developing chordate (amphioxus). Proc Natl Acad Sci U S A 2004, 101:10320-10325.

R49. Markov G, Lecointre G, Demeneix B, Laudet V: The "street light syndrome", or how protein taxonomy can bias experimental manipulations. Bioessays 2008, 30:349-357.
R46. Germain P, Staels B, Dacquet C, Spedding M, Laudet V: Overview of nomenclature of nuclear receptors. Pharmacol Rev 2006, 58:685-704.
R43. Schubert M, Escriva H, Xavier-Neto J, Laudet V: Amphioxus and tunicates as evolutionary model systems. Trends Ecol Evol 2006, 21:269-277.
R41. Gronemeyer H, Gustafsson JA, Laudet V: Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 2004, 3:950-964.
R35. Canaple L, Kakizawa T, Laudet V: The days and nights of cancer cells. Cancer Res 2003, 63:7545-7552.

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